Clenil Modulite 200micrograms / dose inhaler (Chiesi Ltd) 200 dose

Type Pressurised aerosol inhaler (MDI)
Medicine Beclometasone 200micrograms/dose
Adult steroid dose Medium adult steroid dose
Activation mechanism Non breath actuated
Dose counter Has dose counter
Price £9.70 / 30 days
(based on 4 puffs / day)
Inhaled corticosteroid information For children and adults, a total of 4 puffs/day gives a medium dose of ICS
Steroid safety card recommendation (for adults) Steroid safety card recommended
Licences
  • Adult Asthma Licence

Spacers

There are 50 compatible spacers

Training material

Pathways

The use of each medicine included in Right Breathe has been considered in relation to international, national, and regional prescribing pathways. The pathway points at which this medicine is considered a viable prescribing option are included below. If you wish to view the entire pathway, click on its heading, from where you can also access all the prescribing options for each pathway and each pathway point.

Prescribing

Detailed prescribing information is provided below. This content has not been generated by the RightBreathe team, but has been integrated from a 3rd party solution: Multilex (provided by FirstDataBank). Use of this prescribing content is subject to the FirstDataBank disclaimer, which is set out in the "About" section of RightBreathe.

As RightBreathe is a bespoke decision support tool, it covers each and every individual known inhaler option on the UK market to a high level of specificity. Multilex, as a more general resource, does not offer the same level of specificity. There are therefore a small number of medicines for which there are discrepancies between RightBreathe and Multilex content, most notably in relation to licensed particulars and associated licensed doses.

Given the high level of specificity the RightBreathe team work to, details of the individual inhaler licence are most likely to be summarised accurately in the content provided at the top of this page, rather than in the Multilex content below. Where there is ambiguity, users may also wish to refer to individual summaries of product characteristics prior to prescribing.

Dosing

Asthma - prophylaxis

Type Age Range Dose Licensed
Maintenance From 2 years to 18 years 1 actuation - TWICE a DAY - inhalation - using a metered dose device
Maintenance From 18 years 1 actuation - TWICE a DAY - inhalation - using a metered dose device
Maintenance From 12 years to 18 years 2 actuations - TWICE a DAY - inhalation - using a metered dose device
Maintenance From 18 years 2 actuations - TWICE a DAY - inhalation - using a metered dose device
Maintenance From 12 years 4 actuations - TWICE a DAY - inhalation - using a metered dose device

Safety Advice Warnings

Adverse effects (report/action)

  • Corticosteroids may cause growth retardation in children under 18 years
  • During transfer from oral steroids allergic conditions may be unmasked
  • High doses may cause adrenal suppression/bone metabolism changes
  • If growth in children is slowed, consider referral to a paediatrician
  • If visual disturbances occur, perform ophthalmic evaluation
  • Systemic effects possible with any inhaled corticosteroid

Advice concerning formulation

  • Not all formulations are suitable for use in children under 18 years
  • Not all strengths are suitable for use in children under 18 years

Advice on Administration

  • Consider use of a spacer device for suitable patients and formulations
  • Different brands may not be interchangeable

Advice on drug withdrawal

  • Do not withdraw this drug suddenly

Advice on possible excipients

  • Some formulations contain lactose
  • Some formulations may contain alcohol

Discontinue due to test or exam

  • Discontinue if paradoxical bronchospasm occurs

Dose changes (other conditions)

  • Maintain treatment at the lowest effective dose

Patient Counselling

  • Advise patient to rinse mouth with water after each dose
  • Advise patient to seek medical advice if asthma seems to be worsening
  • Advise visual disturbances may affect ability to drive or operate machinery
  • Consider issuing Steroid Treatment/Steroid Emergency Card
  • Ensure patient has a fast acting bronchodilator available
  • High dose:Advise patient to avoid chickenpox,measles etc; see Dr if exposed
  • Patient should seek medical advice if signs of pulmonary infection develop
  • Use regularly to maintain freedom from symptoms

Pre-treatment points to consider

  • Stabilise patient prior to transfer from systemic steroids

Recommended monitoring

  • Check patient is using correct inhaler technique
  • Consider adrenal suppression when transferring from systemic steroid
  • Monitor adrenal function in stressed patients e.g.surgery/intensive care
  • Monitor regularly the height of children receiving prolonged treatment
  • Re-evaluate therapy in active or quiescent pulmonary tuberculosis

Safety/advice in other condition

  • Not to be used to relieve an acute asthmatic attack
  • Systemic corticosteroids may be needed during elective surgery
  • Systemic corticosteroids may be needed during periods of stress

Drug Interactions

With Risk Severity
RIBOCICLIB Increased risk of systemic corticosteroid adverse effects Significant Risk: Usually avoid combination. Use combination only under special circumstances, taking any necessary action to reduce risk.
TIPRANAVIR Increased risk of systemic corticosteroid adverse effects Significant Risk: Usually avoid combination. Use combination only under special circumstances, taking any necessary action to reduce risk.
(INDINAVIR) Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
(NELFINAVIR) Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
(SAQUINAVIR) Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
(TELITHROMYCIN) Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
ATAZANAVIR WITH COBICISTAT Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
CLARITHROMYCIN Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
COBICISTAT Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
DARUNAVIR WITH COBICISTAT Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
DARUNAVIR, COBICISTAT, EMTRICITABINE AND TENOFOVIR ALAFENAMIDE Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
ELVITEGRAVIR, COBICISTAT, EMTRICITABINE AND TENOFOVIR ALAFENAMIDE Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
ELVITEGRAVIR, COBICISTAT, EMTRICITABINE AND TENOFOVIR DISOPROXIL Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
IDELALISIB Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
ITRACONAZOLE Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
KETOCONAZOLE Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
MIFEPRISTONE Corticosteroid effect may be reduced for 3 to 4 days after treatment Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
OMBITASVIR, PARITAPREVIR AND RITONAVIR Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
POSACONAZOLE Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
RITONAVIR Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
VORICONAZOLE Increased risk of systemic corticosteroid adverse effects Moderate Risk: Minimise risk. Take action necessary to reduce risk. Counsel patient.
(DACLATASVIR) Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
(SIMEPREVIR) Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
ALPRAZOLAM Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
AMIODARONE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
AMLODIPINE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
AMPRENAVIR / FOSAMPRENAVIR Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
APREPITANT / FOSAPREPITANT Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
ATAZANAVIR Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
ATORVASTATIN Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
AZITHROMYCIN Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
BICALUTAMIDE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
CICLOSPORIN Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
CILOSTAZOL Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
CIMETIDINE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
CIPROFLOXACIN Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
COMBINED ORAL CONTRACEPTIVES Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
CRIZOTINIB Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
DARUNAVIR Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
DILTIAZEM Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
DRONEDARONE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
ELBASVIR WITH GRAZOPREVIR Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
ERYTHROMYCIN Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
EVEROLIMUS Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
FLUCONAZOLE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
FLUVOXAMINE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
IMATINIB Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
ISAVUCONAZOLE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
ISONIAZID Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
IVACAFTOR Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
LACIDIPINE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
LINAGLIPTIN Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
LOMITAPIDE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
MICONAZOLE (ORAL AND PARENTERAL) Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
NETUPITANT Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
NILOTINIB Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
OBETICHOLIC ACID Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
PALBOCICLIB Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
PAZOPANIB Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
PROPIVERINE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
RANITIDINE / NIZATIDINE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
RANOLAZINE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
STIRIPENTOL Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
TACROLIMUS (ORAL AND PARENTERAL) Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
TERIFLUNOMIDE Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
TOLVAPTAN Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.
VERAPAMIL Increased risk of systemic corticosteroid adverse effects Low Risk: No action needed. Risk of adverse outcomes appears small and depends upon the condition of the patient. Counsel patient.

Precautions

  • Adrenal insufficiency
  • Breastfeeding
  • Children under 18 years
  • Galactosaemia
  • Glucose-galactose malabsorption syndrome
  • Lactose intolerance
  • Major risk factors for decreased bone mineral content
  • Pregnancy
  • Pulmonary tuberculosis

Contraindications

  • None known

Side Effects

  • Adrenal suppression
  • Aggression
  • Anaphylactic reaction
  • Anaphylactoid reaction
  • Anxiety
  • Behavioural disturbances (children)
  • Blurred vision
  • Bronchospasm (paradoxical)
  • Bruising
  • Candidiasis (mouth or throat)
  • Cataracts
  • Cough
  • Cushing's syndrome
  • Cushingoid facies
  • Decrease in bone mineral density
  • Depression
  • Dyspnoea
  • Eosinophilic pneumonia
  • Erythema
  • Facial oedema
  • Glaucoma
  • Growth retardation (children)
  • Headache
  • Hoarseness
  • Hypersensitivity reactions
  • Nausea
  • Ocular oedema
  • Oedema of the lips
  • Oedema of the throat
  • Pruritus
  • Psychomotor hyperactivity
  • Rash
  • Shortness of breath
  • Sleep disturbances
  • Suppression of growth in children and adolescents
  • Systemic effects
  • Thinning of skin
  • Throat irritation
  • Urticaria
  • Visual disturbances
  • Wheezing